The structure of a research-practice partnership will often depend on what’s already in place. Sometimes a partnership emerges from a collaborative evaluation of a program or intervention. Other partnerships are guided by a scholar with an aptitude for doing research in a practice-informed, collaborative way. Still, others are initiated by an agency leader with research-informed instincts and a drive to seek out funding for research-based projects. Whatever the structure or origin, all partnerships represent a commitment to a long-term, mutually beneficial relationship that allows for the emergence of a joint research agenda. This shared purpose shapes specific agreements—memoranda of understanding (MOUs), charters, operating principles—that provide structure and clarity as to how each side of the partnership will work with the other.